Porous reticular Co@Fe metal-organic gel: dual-function simulated peroxidase nanozyme for both colorimetric sensing and antibacterial applications.
J Mater Chem B
; 12(22): 5418-5430, 2024 Jun 05.
Article
in En
| MEDLINE
| ID: mdl-38716837
ABSTRACT
Constructing metal-organic gels (MOGs) with enzyme-catalyzed activity and studying their catalytic mechanism are crucial for the development of novel nanozyme materials. In this study, a Co@Fe MOG with excellent peroxidase activity was developed by a simple and mild one-pot process. The results showed that the material exhibited almost a single peroxidase activity under optimal pH conditions, which allowed it to attract and oxidize the chromogenic substrate 3,3',5,5'-tetramethylbenzidine (TMB). Based on the active electron transfer between the metal centers and the organic ligand in the synthetic material, the Co@Fe MOG-H2O2-TMB system was verified to be able to detect H2O2 and citric acid (CA). The catalytic microenvironment formed by the adsorption and the catalytic center accelerated the electron-transfer rate, which expedited the generation of hydroxyl radicals (ËOH, a kind of reactive oxygen species (ROS)) in the presence of H2O2. The persistence and high intensity of ËOH generation were proven, which would endow Co@Fe MOG with a certain antibacterial ability, promoting the healing of bacteria-infected wounds. In conclusion, this study contributes to the development efforts toward the application systems of nanozymes for marker detection and antibacterial activity.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cobalt
/
Colorimetry
/
Peroxidase
/
Gels
/
Iron
/
Anti-Bacterial Agents
Language:
En
Journal:
J Mater Chem B
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Reino Unido