Emotional Stress Induces Adaptive Response in Rat Lymphocytes to Subsequent Ionizing Radiation Exposure.
Bull Exp Biol Med
; 176(5): 548-554, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38717568
ABSTRACT
We studied the molecular mechanisms of cross-adaptation to ionizing radiation (1 Gy) of lymphocytes isolated from rats subjected to emotional stress. The effects of chronic (CES; various types of stress exposure) and acute (AES; forced swimming) emotional stress in rats on indicators of oxidative stress, cell death, and levels of NRF2 and NOX4 proteins involved in the development of the adaptive response were analyzed in isolated lymphocytes. It was found that stress induced an adaptive response in rat lymphocytes and triggered processes similar to the adaptive response induced by low doses of ionizing radiation an increase in the level of oxidized DNA and cell death, as well as an increase in the content of NOX4 and NRF2 proteins. In animals subjected to emotional stress, suppressed DNA oxidation in response to irradiation, reduced levels of protective factor NRF2, as well as lymphocyte death were observed.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Radiation, Ionizing
/
Stress, Psychological
/
Lymphocytes
/
Oxidative Stress
/
NF-E2-Related Factor 2
Limits:
Animals
Language:
En
Journal:
Bull Exp Biol Med
/
Bull. exp. biol. med
/
Bulletin of experimental biology and medicine
Year:
2024
Document type:
Article
Affiliation country:
Rusia
Country of publication:
Estados Unidos