Early signaling pathways in virus-infected cells.
Curr Opin Virol
; 66: 101411, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38718574
ABSTRACT
Virus infection activates specific pattern recognition receptors and immune signal transduction, resulting in pro-inflammatory cytokine production and activation of innate immunity. We describe here the molecular organization of early signaling pathways downstream of viral recognition, including conformational changes, post-translational modifications, formation of oligomers, and generation of small-molecule second messengers. Such molecular organization allows tight regulation of immune signal transduction, characterized by swift but transient responses, nonlinearity, and signal amplification. Pathologies of early immune signaling caused by genomic mutations illustrate the fine regulation of the immune transduction cascade.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Virus Diseases
/
Signal Transduction
/
Immunity, Innate
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Opin Virol
/
Current opinion in virology (Online)
Year:
2024
Document type:
Article
Affiliation country:
Francia
Country of publication:
Países Bajos