In Situ Measurement of Urea Concentration With an In-Fiber SPR-MZI Sensor.
IEEE Trans Nanobioscience
; 23(3): 403-409, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38722715
ABSTRACT
A fiber-optic urea sensor based on surface plasmon resonance (SPR) and Mach-Zehnder interference (MZI) combined principle was designed and implemented. By plating gold film on the single-mode-no-core-thin-core-single-mode fiber structure, we successfully excited both SPR and MZI, and constructed two parallel detection channels for simultaneously measurement of urea concentration and temperature. Urease was immobilized on the gold film by metal-organic zeolite skeleton (ZIF-8), which can not only fix a large number of urease to improve measurement sensitivity of urea, but also protect urease activity to ensure the sensor stability. Experimental results indicate that the designed urea sensor with temperature compensation function can detect urea solution with concentration of 1-9 mM, and the sensitivity is 1.4 nm/mM. The proposed measurement method provides a new choice for monitoring urea concentration in the field of medical diagnosis and human health monitoring.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Urea
/
Urease
/
Surface Plasmon Resonance
/
Fiber Optic Technology
Language:
En
Journal:
IEEE Trans Nanobioscience
Journal subject:
BIOTECNOLOGIA
Year:
2024
Document type:
Article