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Mechanisms of microbiota modulation: Implications for health, disease, and therapeutic interventions.
Ugwu, Okechukwu Paul-Chima; Alum, Esther Ugo; Okon, Michael Ben; Obeagu, Emmanuel I.
Affiliation
  • Ugwu OP; Department of Publication and Extension, Kampala International University, Kampala, Uganda.
Medicine (Baltimore) ; 103(19): e38088, 2024 May 10.
Article in En | MEDLINE | ID: mdl-38728472
ABSTRACT
Microbiota modulation, the intentional change in the structure and function of the microbial community, is an emerging trajectory that holds the promise to mitigate an infinite number of health issues. The present review illustrates the underlying principles of microbiota modulation and the various applications of this fundamental process to human health, healthcare management, and pharmacologic interventions. Different strategies, directing on dietary interventions, fecal microbiota transplantation, treatment with antibiotics, bacteriophages, microbiome engineering, and modulation of the immune system, are described in detail. This therapeutic implication is reflected in clinical applications to gastrointestinal disorders and immune-mediated diseases for microbiota-modulating agents. In addition to this, the review outlines the challenges of translating researched outcomes into clinical practice to consider safety and provides insights into future research directions of this rapidly developing area.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fecal Microbiota Transplantation / Gastrointestinal Microbiome Limits: Humans Language: En Journal: Medicine (Baltimore) Year: 2024 Document type: Article Affiliation country: Uganda Country of publication: Estados Unidos

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fecal Microbiota Transplantation / Gastrointestinal Microbiome Limits: Humans Language: En Journal: Medicine (Baltimore) Year: 2024 Document type: Article Affiliation country: Uganda Country of publication: Estados Unidos