Effects of ketamine on penile tissues in an experimental priapism model in rats.
Ulus Travma Acil Cerrahi Derg
; 30(5): 309-315, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38738674
ABSTRACT
BACKGROUND:
This study aimed to evaluate the histopathological and biochemical effects of ketamine on penile tissues following ischemia-reperfusion injury induced by priapism.METHODS:
Twenty-four male rats were randomized into three groups. Group 1 served as the control group. Group 2 underwent the priapism model to induce ischemia-reperfusion injury. Group 3, the treatment group, experienced a similar ischemia-reperfusion model as Group 2; additionally, 50 mg/kg of ketamine was administered intraperitoneally just before reperfusion. Blood biochemical analyses and penile histopathological evaluations were performed.RESULTS:
In Group 3, significant improvements were observed in all histopathological scores, including desquamation, edema, inflammation, and vasocongestion compared to Group 2 (p<0.001). Blood biochemical analyses showed that the malondialdehyde (MDA) levels were recorded as 10 in Group 2, with a significant decrease in Group 3 (p=0.013). Similarly, proinflammatory cytokine levels, including interleukin-1 beta (IL-1ß), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), were found to be suppressed in Group 3 compared to Group 2 (p=0.003, p=0.022, and p=0.028, respectively). Antioxidant enzyme activities, such as glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD), were higher in Group 3 compared to Group 2 (p=0.016 and p=0.024, respec-tively).CONCLUSION:
Ketamine is an effective anesthetic agent in alleviating the effects of penile ischemia-reperfusion injury.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Penis
/
Priapism
/
Reperfusion Injury
/
Disease Models, Animal
/
Ketamine
/
Malondialdehyde
Limits:
Animals
Language:
En
Journal:
Ulus Travma Acil Cerrahi Derg
Year:
2024
Document type:
Article