Investigating sensitivity to multi-domain prediction errors in chronic auditory phantom perception.
Sci Rep
; 14(1): 11036, 2024 05 14.
Article
in En
| MEDLINE
| ID: mdl-38744906
ABSTRACT
The perception of a continuous phantom in a sensory domain in the absence of an external stimulus is explained as a maladaptive compensation of aberrant predictive coding, a proposed unified theory of brain functioning. If this were true, these changes would occur not only in the domain of the phantom percept but in other sensory domains as well. We confirm this hypothesis by using tinnitus (continuous phantom sound) as a model and probe the predictive coding mechanism using the established local-global oddball paradigm in both the auditory and visual domains. We observe that tinnitus patients are sensitive to changes in predictive coding not only in the auditory but also in the visual domain. We report changes in well-established components of event-related EEG such as the mismatch negativity. Furthermore, deviations in stimulus characteristics were correlated with the subjective tinnitus distress. These results provide an empirical confirmation that aberrant perceptions are a symptom of a higher-order systemic disorder transcending the domain of the percept.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Auditory Perception
/
Tinnitus
/
Electroencephalography
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Sci Rep
Year:
2024
Document type:
Article
Affiliation country:
Irlanda
Country of publication:
Reino Unido