The Management of Mild Pulmonary Hypertension in Clinical Practice.
Ann Am Thorac Soc
; 21(8): 1115-1123, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38747696
ABSTRACT
The definition of pulmonary hypertension (PH) has been revised recently, with the mean pulmonary artery pressure (mPAP) threshold (assessed by right heart catheterization) reduced from ⩾25 mm Hg to >20 mm Hg. This change reflects the mPAP upper limit of normal and a lower limit that is independently associated with adverse outcomes. To improve the specificity of diagnosing pathogenic increases in mPAP, however, a diagnosis of precapillary PH now also includes pulmonary vascular resistance >2.0 Wood units (WU) (lowered from >3.0 WU). These changes are positioned to capture approximately 55% more patients with PH. Because all clinical trials showing a benefit of pulmonary vasodilator therapy in precapillary PH used the classical hemodynamic definition, the approach to the diagnosis and management of patients with mild PH (i.e., mPAP 21-24 mm Hg and pulmonary vascular resistance 2-3 WU) requires particular consideration. Here, we use a question/answer format to discuss key areas in the management of mild PH, including practical information tailored to clinicians without training in PH.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vascular Resistance
/
Vasodilator Agents
/
Cardiac Catheterization
/
Hypertension, Pulmonary
Limits:
Humans
Language:
En
Journal:
Ann Am Thorac Soc
Year:
2024
Document type:
Article
Affiliation country:
Austria
Country of publication:
Estados Unidos