Next-generation sequencing technologies for helminth diagnostics and surveillance in ruminants: shifting diagnostic barriers.
Trends Parasitol
; 40(6): 511-526, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38760257
ABSTRACT
Helminth infections in grazing ruminants are a major issue for livestock farming globally, but are unavoidable in outdoor grazing systems and must be effectively managed to avoid deleterious effects to animal health, and productivity. Next-generation sequencing (NGS) technologies are transforming our understanding of the genetic basis of anthelmintic resistance (AR) and epidemiological studies of ruminant gastrointestinal parasites. They also have the potential to not only help develop and validate molecular diagnostic tests but to be directly used in routine diagnostics integrating species-specific identification and AR into a single test. Here, we review how these developments have opened the pathway for the development of multi-AR and multispecies identification in a single test, with widespread implications for sustainable livestock farming for the future.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ruminants
/
High-Throughput Nucleotide Sequencing
/
Helminthiasis, Animal
Limits:
Animals
Language:
En
Journal:
Trends Parasitol
Journal subject:
PARASITOLOGIA
Year:
2024
Document type:
Article