Relative Bioavailability Assessment of Solid Forms by An Artificial Stomach and Duodenum Apparatus.
J Pharm Sci
; 2024 May 18.
Article
in En
| MEDLINE
| ID: mdl-38768754
ABSTRACT
In this work, the ability of the artificial stomach and duodenum (ASD) model to predict bioavailability in rats was investigated using a poorly soluble model compound, BI-639667. A solution and four suspensions of different solid forms of BI-639667 were tested both in an ASD and rats. Rank order of the bioavailability estimated from an ASD apparatus is consistent with that of in vivo result in rats, i.e., solution > salicylic acid cocrystal > malate salt > maleate salt > monohydrate, which correlates with the ability of the different solid forms to maintain supersaturation with respect to the stable form in aqueous solution. The results support the use of an ASD for characterizing dissolution performance of solid forms to aid their selection for tablet formulation development.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Pharm Sci
Year:
2024
Document type:
Article
Affiliation country:
Estados Unidos