To slide or not to slide: key role of the hexasome in chromatin remodeling revealed.
Nat Struct Mol Biol
; 31(5): 742-746, 2024 May.
Article
in En
| MEDLINE
| ID: mdl-38769465
ABSTRACT
Hexasomes are non-canonical nucleosomes that package DNA with six instead of eight histones. First discovered 40 years ago as a consequence of transcription, two near-atomic-resolution cryo-EM structures of the hexasome in complex with the chromatin remodeler INO80 have now started to unravel its mechanistic impact on the regulatory landscape of chromatin. Loss of one histone H2A-H2B dimer converts inactive nucleosomes into distinct and favorable substrates for ATP-dependent chromatin remodeling.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Histones
/
Nucleosomes
/
Cryoelectron Microscopy
/
Chromatin Assembly and Disassembly
Limits:
Humans
Language:
En
Journal:
Nat Struct Mol Biol
Journal subject:
BIOLOGIA MOLECULAR
Year:
2024
Document type:
Article
Country of publication:
Estados Unidos