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Cholesterol neutralized vemurafenib treatment by promoting melanoma stem-like cells via its metabolite 27-hydroxycholesterol.
Wang, Xiaohong; Zhong, Feiliang; Chen, Tingting; Wang, Hongbo; Wang, Weifang; Jin, Hongkai; Li, Chouyang; Guo, Xuan; Liu, Ying; Zhang, Yu; Li, Bo.
Affiliation
  • Wang X; Liaoning Technology and Engineering Center for Tumor Immunology and Molecular Theranotics, Collaborative Innovation Center for Age-Related Disease, Life Science Institute of Jinzhou Medical University, Jinzhou, 121001, Liaoning, China.
  • Zhong F; College of Basic Medical Science, Jinzhou Medical University, Jinzhou, 121001, Liaoning, China.
  • Chen T; Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education, College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, People's Republic of China.
  • Wang H; School of Basic Medicine, Guangdong Medical University, Dongguan, 523808, Guangdong, China.
  • Wang W; Liaoning Technology and Engineering Center for Tumor Immunology and Molecular Theranotics, Collaborative Innovation Center for Age-Related Disease, Life Science Institute of Jinzhou Medical University, Jinzhou, 121001, Liaoning, China.
  • Jin H; College of Basic Medical Science, Jinzhou Medical University, Jinzhou, 121001, Liaoning, China.
  • Li C; Liaoning Technology and Engineering Center for Tumor Immunology and Molecular Theranotics, Collaborative Innovation Center for Age-Related Disease, Life Science Institute of Jinzhou Medical University, Jinzhou, 121001, Liaoning, China.
  • Guo X; College of Basic Medical Science, Jinzhou Medical University, Jinzhou, 121001, Liaoning, China.
  • Liu Y; Liaoning Technology and Engineering Center for Tumor Immunology and Molecular Theranotics, Collaborative Innovation Center for Age-Related Disease, Life Science Institute of Jinzhou Medical University, Jinzhou, 121001, Liaoning, China.
  • Zhang Y; College of Basic Medical Science, Jinzhou Medical University, Jinzhou, 121001, Liaoning, China.
  • Li B; Liaoning Technology and Engineering Center for Tumor Immunology and Molecular Theranotics, Collaborative Innovation Center for Age-Related Disease, Life Science Institute of Jinzhou Medical University, Jinzhou, 121001, Liaoning, China.
Cell Mol Life Sci ; 81(1): 226, 2024 May 22.
Article in En | MEDLINE | ID: mdl-38775844
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Stem Cells / Cholesterol / Cell Proliferation / Cholestanetriol 26-Monooxygenase / Vemurafenib / Hydroxycholesterols / Melanoma Limits: Animals / Humans Language: En Journal: Cell Mol Life Sci Journal subject: BIOLOGIA MOLECULAR Year: 2024 Document type: Article Affiliation country: China Country of publication: Suiza
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Stem Cells / Cholesterol / Cell Proliferation / Cholestanetriol 26-Monooxygenase / Vemurafenib / Hydroxycholesterols / Melanoma Limits: Animals / Humans Language: En Journal: Cell Mol Life Sci Journal subject: BIOLOGIA MOLECULAR Year: 2024 Document type: Article Affiliation country: China Country of publication: Suiza