Pericytes in Alzheimer's disease: Key players and therapeutic targets.
Exp Neurol
; 379: 114825, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-38777251
ABSTRACT
Alzheimer's disease (AD) is a devastating neurodegenerative disorder that leads to progressive cognitive decline and neuropathological changes. Pericytes, which are vessel mural cells on the basement membrane of capillaries, play a crucial role in regulating cerebrovascular functions and maintaining neurovascular unit integrity. Emerging research substantiates the involvement of pericytes in AD. This review provides a comprehensive overview of pericytes, including their structure, origin, and markers and various functions within the central nervous system. Emphatically, the review explores the intricate mechanisms through which pericytes contribute to AD, including their interactions with amyloid beta and apolipoprotein E, as well as various signaling pathways. The review also highlights potential for targeted pericyte therapy for AD, with a focus on stem cell therapy and drug treatments. Future research directions include the classification of pericyte subtypes, studies related to aging, and the role of pericytes in exosome-related mechanisms in AD pathology. In conclusion, this review consolidates current knowledge on the pivotal roles of pericytes in AD and their potential as therapeutic targets, providing valuable insights for future research and clinical interventions aimed at addressing the impact of AD on patients' lives.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pericytes
/
Alzheimer Disease
Limits:
Animals
/
Humans
Language:
En
Journal:
Exp Neurol
Year:
2024
Document type:
Article
Affiliation country:
China