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Large-scale mutational analysis identifies UNC93B1 variants that drive TLR-mediated autoimmunity in mice and humans.
Rael, Victoria E; Yano, Julian A; Huizar, John P; Slayden, Leianna C; Weiss, Madeleine A; Turcotte, Elizabeth A; Terry, Jacob M; Zuo, Wenqi; Thiffault, Isabelle; Pastinen, Tomi; Farrow, Emily G; Jenkins, Janda L; Becker, Mara L; Wong, Stephen C; Stevens, Anne M; Otten, Catherine; Allenspach, Eric J; Bonner, Devon E; Bernstein, Jonathan A; Wheeler, Matthew T; Saxton, Robert A; Liu, Bo; Majer, Olivia; Barton, Gregory M.
Affiliation
  • Rael VE; Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
  • Yano JA; Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
  • Huizar JP; Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
  • Slayden LC; Division of Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Weiss MA; Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
  • Turcotte EA; Howard Hughes Medical Institute, University of California, Berkeley , Berkeley, CA, USA.
  • Terry JM; Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
  • Zuo W; Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
  • Thiffault I; Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
  • Pastinen T; Howard Hughes Medical Institute, University of California, Berkeley , Berkeley, CA, USA.
  • Farrow EG; Division of Immunology and Molecular Medicine, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
  • Jenkins JL; Department of Pathology and Laboratory Medicine, Children's Mercy Hospital, Kansas City, MO, USA.
  • Becker ML; Genomic Medicine Center, Children's Mercy Hospital , Kansas City, MO, USA.
  • Wong SC; University of Missouri Kansas City School of Medicine , Kansas City, MO, USA.
  • Stevens AM; Genomic Medicine Center, Children's Mercy Hospital , Kansas City, MO, USA.
  • Otten C; University of Missouri Kansas City School of Medicine , Kansas City, MO, USA.
  • Allenspach EJ; Department of Pathology and Laboratory Medicine, Children's Mercy Hospital, Kansas City, MO, USA.
  • Bonner DE; Genomic Medicine Center, Children's Mercy Hospital , Kansas City, MO, USA.
  • Bernstein JA; University of Missouri Kansas City School of Medicine , Kansas City, MO, USA.
  • Wheeler MT; Department of Genetics, Children's Mercy Hospital, Kansas City, MO, USA.
  • Saxton RA; Division of Rheumatology, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.
  • Liu B; Division of Rheumatology, Department of Pediatrics, Seattle Children's Hospital, Seattle, WA, USA.
  • Majer O; Johnson & Johnson Innovative Medicine , Spring House, PA, USA.
  • Barton GM; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.
J Exp Med ; 221(8)2024 Aug 05.
Article in En | MEDLINE | ID: mdl-38780621
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Transport Proteins / Autoimmunity / Toll-Like Receptors Limits: Animals / Female / Humans / Male Language: En Journal: J Exp Med Year: 2024 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Transport Proteins / Autoimmunity / Toll-Like Receptors Limits: Animals / Female / Humans / Male Language: En Journal: J Exp Med Year: 2024 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos