Effects of propofol, ketamine-propofol mixture in pediatric dental patients undergoing intravenous sedation: a clinical study.
Sci Rep
; 14(1): 11806, 2024 05 23.
Article
in En
| MEDLINE
| ID: mdl-38782977
ABSTRACT
This study aimed to evaluate the clinical effects, complications (peri- and postoperative), depth of sedation, recovery times, and changes in anxiety levels in paediatric dental patients receiving intravenous sedation with propofol and ketamine-propofol mixtures. This prospective clinical study included 69 healthy children (ASA 1) aged 3-7 years. The patients were assigned randomly to propofol group (n = 23), which received propofol; 13 ketofol group (n = 23), which received 13 ketofol; or 14 ketofol group (n = 23), which received 14 ketofol. The bispectral index (BIS) and Ramsay Sedation Scale (RSS) score were recorded at intervals of 5 min to measure the depth of sedation, and vital signs were evaluated. Peri- and postoperative complications and recovery times were recorded. Anxiety levels were also evaluated using the Facial Image Scale (FIS) and changes in saliva cortisol levels (SCLs) before and after the intravenous sedation procedure. The KruskalâWallis test and Wilcoxon signed-rank test were used to determine pre- and posttreatment parameters. Dunn's test for post hoc analysis was used to determine the differences among groups. Children's pre- and posttreatment anxiety levels did not differ significantly according to FIS scores, and increases in SCLs were detected in 13 ketofol and 14 ketofol groups after dental treatment was completed. Compared with those in the other groups, the BIS values of the patients in 14 ketofol indicated a slightly lower depth of sedation. The recovery time of the patients in 13 ketofol was longer than that of patients in propofol and 14 ketofol. The incidence of postoperative complications (agitation, hypersalivation, nausea/vomiting, and diplopia) did not differ among the groups. Ketamine-propofol combinations provided effective sedation similar to that of propofol infusion without any serious complications during dental treatment performed under intravenous sedation. The ketofol infusion increased the anxiety level of paediatric dental patients to a greater extent than the propofol infusion.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Propofol
/
Ketamine
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
En
Journal:
Sci Rep
Year:
2024
Document type:
Article
Affiliation country:
Turquía