Examination of SARS-CoV-2 RNA in joint synovial fluid of patients with COVID-19 and acute knee arthritis.
Technol Health Care
; 32(5): 3793-3800, 2024.
Article
in En
| MEDLINE
| ID: mdl-38788104
ABSTRACT
BACKGROUND:
It has not yet been fully established that there is coronavirus disease 2019 (COVID-19) involvement in the synovial fluid and it remains a topic of debate.OBJECTIVE:
The aim of this study was to evaluate the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in knee joint synovial fluid of patients with COVID-19.METHODS:
This retrospective study was conducted with an initial screening of patients who were admitted to a tertiary pandemic hospital due to COVID-19 symptoms, and underwent treatment for COVID-19 between March and June 2020.RESULTS:
A total of 2476 patients were hospitalized or received treatment for a possible diagnosis of COVID-19. While the RT-PCR test was positive in 318 patients (12.8%), 2158 (87.2%) were computed tomography positive but reverse transcription-polymerase chain reaction (RT-PCR) negative. Twelve patients were consulted due to acute joint effusion. Of five patients with knee joint effusion and a positive RT-PCR test, the synovial tissue RT-PCR test was positive in only one patient.CONCLUSION:
This paper is the first to show the presence of SARS-CoV-2 in synovial fluid. This can be considered of importance for the determination and elimination of the route of transmission, thereby preventing further development and spread of the disease.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Synovial Fluid
/
RNA, Viral
/
SARS-CoV-2
/
COVID-19
/
Knee Joint
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Technol Health Care
/
Technol. health care
/
Technology and health care
Journal subject:
ENGENHARIA BIOMEDICA
/
SERVICOS DE SAUDE
Year:
2024
Document type:
Article
Affiliation country:
Turquía
Country of publication:
Países Bajos