SARS-CoV-2 and Influenza Co-Infection: Fair Competition or Sinister Combination?
Viruses
; 16(5)2024 05 16.
Article
in En
| MEDLINE
| ID: mdl-38793676
ABSTRACT
The COVID-19 pandemic remains a serious public health problem globally. During winter influenza seasons, more aggressive SARS-CoV-2 infections and fatalities have been documented, indicating that influenza co-infections may significantly impact the disease outcome of COVID-19. Both influenza and SARS-CoV-2 viruses share many similarities in their transmission and their cellular tropism for replication in the human respiratory tract. However, the complex intricacies and multi-faceted dynamics of how the two pathogens interact to ensure their survival in the same lung microenvironment are still unclear. In addition, clinical studies on influenza co-infections in COVID-19 patients do not provide conclusive evidence of how influenza co-infection mechanistically modifies disease outcomes of COVID-19. This review discusses various viral as well as host factors that potentially influence the survival or synergism of these two respiratory pathogens in the infected lung microenvironment.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Influenza, Human
/
Coinfection
/
SARS-CoV-2
/
COVID-19
/
Lung
Limits:
Animals
/
Humans
Language:
En
Journal:
Viruses
Year:
2024
Document type:
Article
Affiliation country:
India
Country of publication:
Suiza