The Coronavirus helicase in replication.
Virus Res
; 346: 199401, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38796132
ABSTRACT
The coronavirus nonstructural protein (nsp) 13 encodes an RNA helicase (nsp13-HEL) with multiple enzymatic functions, including unwinding and nucleoside phosphatase (NTPase) activities. Attempts for enzymatic inactivation have defined the nsp13-HEL as a critical enzyme for viral replication and a high-priority target for antiviral development. Helicases have been shown to play numerous roles beyond their canonical ATPase and unwinding activities, though these functions are just beginning to be explored in coronavirus biology. Recent genetic and biochemical studies, as well as work in structurally-related helicases, have provided evidence that supports new hypotheses for the helicase's potential role in coronavirus replication. Here, we review several aspects of the coronavirus nsp13-HEL, including its reported and proposed functions in viral replication and highlight fundamental areas of research that may aid the development of helicase inhibitors.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Virus Replication
/
Viral Nonstructural Proteins
/
RNA Helicases
Limits:
Animals
/
Humans
Language:
En
Journal:
Virus Res
Journal subject:
VIROLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Estados Unidos