Increased CSF DOPA Decarboxylase Correlates with Lower DaT-SPECT Binding: Analyses in Biopark and PPMI Cohorts.
Mov Disord
; 2024 May 26.
Article
in En
| MEDLINE
| ID: mdl-38798037
ABSTRACT
BACKGROUND:
Recent studies identified increased cerebrospinal fluid (CSF) DOPA decarboxylase (DDC) as a promising biomarker for parkinsonian disorders, suggesting a compensation to dying dopaminergic neurons. A correlation with 123I-FP-CIT-SPECT (DaT-SPECT) imaging could shed light on this link.OBJECTIVE:
The objective is to assess the relationship between CSF DDC levels and DaT-SPECT binding values.METHODS:
A total of 51 and 72 Parkinson's disease (PD) subjects with available DaT-SPECT and CSF DDC levels were selected from the PPMI and Biopark cohorts, respectively. DDC levels were analyzed using proximity extension assay and correlated with DaT-SPECT striatal binding ratios (SBR). All analyses were corrected for age and sex.RESULTS:
CSF DDC levels in PD patients correlated negatively with DaT-SPECT SBR in both putamen and caudate nucleus. Additionally, SBR decreased with increased DDC levels over time in PD patients.CONCLUSION:
CSF DDC levels negatively correlate with DaT-SPECT SBR in levodopa-treated PD. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Mov Disord
Journal subject:
NEUROLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Suecia
Country of publication:
Estados Unidos