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Ebselen analogues delay disease onset and its course in fALS by on-target SOD-1 engagement.
Watanabe, Seiji; Amporndanai, Kangsa; Awais, Raheela; Latham, Caroline; Awais, Muhammad; O'Neill, Paul M; Yamanaka, Koji; Hasnain, S Samar.
Affiliation
  • Watanabe S; Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Furo-Cho, Chikusa-Ku, Nagoya, 464-8601, Japan.
  • Amporndanai K; Molecular Biophysics Group, Department of Biochemistry and System Biology, Institute of System, M0polecular and Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, L69 7ZB, UK.
  • Awais R; Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, TN, 37232, USA.
  • Latham C; School of Life Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, L69 7ZB, UK.
  • Awais M; School of Life Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, L69 7ZB, UK.
  • O'Neill PM; Department of Molecular and Clinical Cancer Medicine, Institute of System, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 3GE, UK.
  • Yamanaka K; Department of Chemistry, Faculty of Science and Engineering, University of Liverpool, Liverpool, L69 7ZD, UK. P.M.Oneill01@liverpool.ac.uk.
  • Hasnain SS; Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Furo-Cho, Chikusa-Ku, Nagoya, 464-8601, Japan. koji.yamanaka@riem.nagoya-u.ac.jp.
Sci Rep ; 14(1): 12118, 2024 05 27.
Article in En | MEDLINE | ID: mdl-38802492
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azoles / Organoselenium Compounds / Isoindoles / Superoxide Dismutase-1 / Amyotrophic Lateral Sclerosis Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2024 Document type: Article Affiliation country: Japón Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azoles / Organoselenium Compounds / Isoindoles / Superoxide Dismutase-1 / Amyotrophic Lateral Sclerosis Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2024 Document type: Article Affiliation country: Japón Country of publication: Reino Unido