Influence of intersignaling crosstalk on the intracellular localization of YAP/TAZ in lung cells.
Cell Commun Signal
; 22(1): 289, 2024 May 27.
Article
in En
| MEDLINE
| ID: mdl-38802925
ABSTRACT
A cell is a dynamic system in which various processes occur simultaneously. In particular, intra- and intercellular signaling pathway crosstalk has a significant impact on a cell's life cycle, differentiation, proliferation, growth, regeneration, and, consequently, on the normal functioning of an entire organ. Hippo signaling and YAP/TAZ nucleocytoplasmic shuttling play a pivotal role in normal development, homeostasis, and tissue regeneration, particularly in lung cells. Intersignaling communication has a significant impact on the core components of the Hippo pathway and on YAP/TAZ localization. This review describes the crosstalk between Hippo signaling and key lung signaling pathways (WNT, SHH, TGFß, Notch, Rho, and mTOR) using lung cells as an example and highlights the remaining unanswered questions.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transcription Factors
/
Signal Transduction
/
Lung
Limits:
Animals
/
Humans
Language:
En
Journal:
Cell Commun Signal
Year:
2024
Document type:
Article
Affiliation country:
Rusia