Structure-based discovery and rational design of microtubule-targeting agents.
Curr Opin Struct Biol
; 87: 102845, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38805950
ABSTRACT
Microtubule-targeting agents (MTAs) have demonstrated remarkable efficacy as antitumor, antifungal, antiparasitic, and herbicidal agents, finding applications in the clinical, veterinary, and agrochemical industry. Recent advances in tubulin and microtubule structural biology have provided powerful tools that pave the way for the rational design of innovative small-molecule MTAs for future basic and applied life science applications. In this mini-review, we present the current status of the tubulin and microtubule structural biology field, the recent impact it had on the discovery and rational design of MTAs, and exciting avenues for future MTA research.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tubulin
/
Tubulin Modulators
/
Microtubules
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Opin Struct Biol
Journal subject:
BIOLOGIA MOLECULAR
Year:
2024
Document type:
Article
Country of publication:
Reino Unido