Hypervalent Iodine Amino Acid Building Blocks for Bioorthogonal Peptide Macrocyclization.
Angew Chem Int Ed Engl
; 63(33): e202404747, 2024 Aug 12.
Article
in En
| MEDLINE
| ID: mdl-38807563
ABSTRACT
Ethynylbenziodoxol(on)es (EB(X)xs) reagents have emerged as useful reagents for peptide/protein modification due to their versatile reactivity and high selectivity. Herein, we report the successful introduction of ethynylbenziodoxoles (EBxs) on different amino acid building blocks (Lys/Orn/Dap), and show their compatibility with both solid phase peptide synthesis (SPPS) and solution phase peptide synthesis (SPS). The selective incorporation of the EBx core into peptide sequences enable efficient macrocyclizations under mild conditions for the synthesis of topologically unique cyclic and bicyclic peptides.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptides
/
Amino Acids
/
Iodine
Language:
En
Journal:
Angew Chem Int Ed Engl
/
Angew. Chem. (Int. ed., Internet)
/
Angewandte Chemie (International ed. Internet)
Year:
2024
Document type:
Article
Affiliation country:
Suiza
Country of publication:
Alemania