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Levofloxacin prophylaxis for pediatric leukemia patients: monitoring of outcomes for sustained benefit and consequences.
Davis, Andrea L; Stevens, Alexandra M; Brackett, Julienne; Marquez, Lucila; Foster, Catherine E; Clemente, Adriana Sarmiento; Sauer, Hannah E; Stimes, Grant T; Campbell, Judith R.
Affiliation
  • Davis AL; Department Infection Control and Prevention, Texas Children's Hospital, Houston, TX, USA.
  • Stevens AM; Department of Pediatrics, Section of Hematology Oncology, Baylor College of Medicine, Houston, TX, USA.
  • Brackett J; Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX, USA.
  • Marquez L; Department of Pediatrics, Section of Hematology Oncology, Baylor College of Medicine, Houston, TX, USA.
  • Foster CE; Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX, USA.
  • Clemente AS; Department Infection Control and Prevention, Texas Children's Hospital, Houston, TX, USA.
  • Sauer HE; Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, TX, USA.
  • Stimes GT; Department Infection Control and Prevention, Texas Children's Hospital, Houston, TX, USA.
  • Campbell JR; Department of Pediatrics, Division of Infectious Diseases, Baylor College of Medicine, Houston, TX, USA.
Antimicrob Steward Healthc Epidemiol ; 4(1): e90, 2024.
Article in En | MEDLINE | ID: mdl-38807931
ABSTRACT
Levofloxacin prophylaxis reduces bloodstream infections in neutropenic patients with acute myeloid leukemia or relapsed acute lymphoblastic leukemia. A retrospective, longitudinal cohort study compares incidence of bacteremia, multidrug-resistant organisms (MDRO), and Clostridioides difficile (CDI) between time periods of levofloxacin prophylaxis implementation. Benefits were sustained without increasing MDRO or CDI.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Antimicrob Steward Healthc Epidemiol Year: 2024 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Antimicrob Steward Healthc Epidemiol Year: 2024 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido