Protocol for a seamless phase 2A-phase 2B randomized double-blind placebo-controlled trial to evaluate the safety and efficacy of benfotiamine in patients with early Alzheimer's disease (BenfoTeam).

Feldman, Howard H; Luchsinger, José A; Léger, Gabriel C; Taylor, Curtis; Jacobs, Diane M; Salmon, David P; Edland, Steven D; Messer, Karen; Revta, Carolyn; Flowers, Sarah A; Jones, Kerry S; Koulman, Albert; Yarasheski, Kevin E; Verghese, Philip B; Venkatesh, Venky; Zetterberg, Henrik; Durant, January; Lupo, Jody-Lynn; Gibson, Gary E

Feldman, Howard H; Luchsinger, José A; Léger, Gabriel C; Taylor, Curtis; Jacobs, Diane M; Salmon, David P; Edland, Steven D; Messer, Karen; Revta, Carolyn; Flowers, Sarah A; Jones, Kerry S; Koulman, Albert; Yarasheski, Kevin E; Verghese, Philip B; Venkatesh, Venky; Zetterberg, Henrik; Durant, January; Lupo, Jody-Lynn; Gibson, Gary E.

Affiliation

Feldman HH; Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America.
Luchsinger JA; Alzheimer's Disease Cooperative Study, University of California San Diego, La Jolla, California, United States of America.
Léger GC; Shiley-Marcos Alzheimer's Disease Research Center, La Jolla, California, United States of America.
Taylor C; Columbia University Irving Medical Center, New York, New York, United States of America.
Jacobs DM; Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America.
Salmon DP; Alzheimer's Disease Cooperative Study, University of California San Diego, La Jolla, California, United States of America.
Edland SD; Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America.
Messer K; Alzheimer's Disease Cooperative Study, University of California San Diego, La Jolla, California, United States of America.
Revta C; Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America.
Flowers SA; Alzheimer's Disease Cooperative Study, University of California San Diego, La Jolla, California, United States of America.
Jones KS; Shiley-Marcos Alzheimer's Disease Research Center, La Jolla, California, United States of America.
Koulman A; Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America.
Yarasheski KE; Alzheimer's Disease Cooperative Study, University of California San Diego, La Jolla, California, United States of America.
Verghese PB; Shiley-Marcos Alzheimer's Disease Research Center, La Jolla, California, United States of America.
Venkatesh V; Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America.
Zetterberg H; Alzheimer's Disease Cooperative Study, University of California San Diego, La Jolla, California, United States of America.
Durant J; Shiley-Marcos Alzheimer's Disease Research Center, La Jolla, California, United States of America.
Lupo JL; Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America.
Gibson GE; Alzheimer's Disease Cooperative Study, University of California San Diego, La Jolla, California, United States of America.

PLoS One ; 19(5): e0302998, 2024.

Article in En | MEDLINE | ID: mdl-38809849

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiamine / Alzheimer Disease Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2024 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos

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