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Antioxidant effects of Paeoniflorin and relevant molecular mechanisms as related to a variety of diseases: A review.
Lu, Yansong; Yin, Lu; Yang, Wei; Wu, Ze; Niu, Jun.
Affiliation
  • Lu Y; Department of Dermatology, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenhe District, Shenyang 110016, China.
  • Yin L; Department of Dermatology, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenhe District, Shenyang 110016, China.
  • Yang W; Department of Dermatology, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenhe District, Shenyang 110016, China.
  • Wu Z; Department of Dermatology, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenhe District, Shenyang 110016, China.
  • Niu J; Department of Dermatology, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenhe District, Shenyang 110016, China. Electronic address: niujun06@126.com.
Biomed Pharmacother ; 176: 116772, 2024 Jul.
Article in En | MEDLINE | ID: mdl-38810407
ABSTRACT
Paeoniflorin (PF), which is the main component of the Paeonia lactiflora Pall extract, is one of the traditional Chinese medicines. The pharmacological effects associated with PF include antioxidant, immunomodulatory, anti-inflammatory, anticancer, antidepressant-like and neuroprotective effects. Our previous studies had revealed that PF protected melanocytes and inhibited photodamage through the suppression of oxidative stress (OS). As OS plays a vital role in the progression of a variety of diseases, the capacity for PF to suppress OS may exert important effects upon them. However, no review exists on these antioxidant effects of PF as related to various diseases. Therefore, in this review we summarized studies involved with examining the antioxidant effects and molecular mechanisms of PF. Through its capacity to inhibit OS, PF has been shown to exert beneficial effects upon several systems including nervous, cardiac/vascular, digestive, and respiratory as well as specific diseases such as diabetes, autoimmune, pregnancy related, ocular, kidney, dermatology, along with suppression of distal flap necrosis, postoperative adhesions, and hearing loss. Such findings provide new insights and directions for future research directed at the development of PF as a natural antioxidant for the treatment of clinical diseases.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxidative Stress / Monoterpenes / Glucosides / Antioxidants Limits: Animals / Humans Language: En Journal: Biomed Pharmacother / Biomed. pharmacother / Biomedicine & pharmacotherapy Year: 2024 Document type: Article Country of publication: Francia

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxidative Stress / Monoterpenes / Glucosides / Antioxidants Limits: Animals / Humans Language: En Journal: Biomed Pharmacother / Biomed. pharmacother / Biomedicine & pharmacotherapy Year: 2024 Document type: Article Country of publication: Francia