Effect of Transplanted Bone Marrow on Spleen of Irradiated Pregnant Rats and Their Fetuses.
Pak J Biol Sci
; 27(4): 168-181, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38812108
ABSTRACT
<b>Background and Objective:
</b> Prenatal ionizing radiation exposure may hinder fetal and embryonic growth depending on the dose and gestational age. The current study's objective was to discover how bone marrow transplants affected the spleens of pregnant rats that had been subjected to γ (Gamma) radiation. <b>Materials andMethods:
</b> Sixty rats that were pregnant were separated into five different groups, each with 6 females. The pregnant rats in the second Group were exposed to 2Gy of γ-rays. Group III; pregnant rats subjected to 2Gy of γ-rays, followed by an intraperitoneal injection of newly prepared bone marrow transplantation (BMT). The fifth Group were exposed to 2Gy γ-rays and received 1 dosage of BMT an hour later. Spleen samples from the pregnant rats as well as their fetuses were taken for histological and histochemical analyses. <b>Results:
</b> Gamma rays damaged the splenic tissue of women and their fetuses on days 7 or 14 of pregnancy in a variety of histological and histochemical ways, although bone marrow transplantation significantly reduced the damage. Treated mothers with bone marrow post-radiation showed a noticeable recovery in spleen of their fetuses. Improved spleen architecture was accompanied by appearance of normal content of collagen, polysaccharides and total protein in the fetal spleen tissue especially on day 7 of gestation. <b>Conclusion:
</b> Bone marrow transplantation can lessen the damage caused by gamma radiation.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spleen
/
Bone Marrow Transplantation
/
Fetus
/
Gamma Rays
Limits:
Animals
/
Pregnancy
Language:
En
Journal:
Pak J Biol Sci
/
Pak. j. biol. sci
/
Pakistan journal of biological sciences
Year:
2024
Document type:
Article
Country of publication:
Pakistán