Refining the circuits of drug addiction: The ventral pallidum.
Curr Opin Neurobiol
; 86: 102883, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38815544
ABSTRACT
The ventral pallidum is a prominent structure within the basal ganglia, regulating reward and motivational processes. Positioned at the interface between motor and limbic structures, its function is crucial to the development and maintenance of substance use disorders. Chronic drug use induces neuroplastic events in this structure, leading to long-term changes in VP neuronal activity and synaptic communication. Moreover, different neuronal populations within the VP drive drug-seeking behavior in opposite directions. This review explores the role of the VP as a hub for reward, motivation, and aversion, establishing it as an important contributor to the pathophysiology of substance use disorders.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Substance-Related Disorders
/
Basal Forebrain
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Opin Neurobiol
Journal subject:
BIOLOGIA
/
NEUROLOGIA
Year:
2024
Document type:
Article
Country of publication:
Reino Unido