A patent review of P2X7 receptor antagonists to treat inflammatory diseases (2018-present).
Expert Opin Ther Pat
; 34(4): 263-271, 2024 Apr.
Article
in En
| MEDLINE
| ID: mdl-38828613
ABSTRACT
INTRODUCTION:
The purinergic P2X7 receptor (P2X7R) is expressed on the surface of many different types of cells, including immune cells. Targeting P2X7R with antagonists has been studied for its potential therapeutic effects in a variety of inflammatory illnesses. AREA COVERED Many chemical substances, including carboxamides, benzamides and nitrogen containing heterocyclic derivatives have demonstrated promising inhibitory potential for P2X7 receptor. The chemistry and clinical applications of P2X7R antagonists patented from 2018- present are discussed in this review. EXPERT OPINION Purinergic receptor inhibitor discovery and application has demonstrated the potential for therapeutic intervention, as demonstrated by pharmacological research. Few chemical modalities have been authorized for use in clinical settings, despite the fact that breakthroughs in crystallography and chemical biology have increased the knowledge of purinergic signaling and its consequences in disease. The many research projects and pharmaceutical movements that sustain dynamic P2X receptor programs over decades are evidence of the therapeutic values and academic persistence in purinergic study. P2X7R is an intriguing therapeutic target and possible biomarker for inflammation. Although several companies like Merck and AstraZeneca have published patents on P2X3 antagonists, the search for P2X7R antagonists has not stopped. Numerous pharmaceutical companies have disclosed different scaffolds, and some molecules are presently being studied in clinical studies.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Patents as Topic
/
Receptors, Purinergic P2X7
/
Purinergic P2X Receptor Antagonists
/
Inflammation
Limits:
Animals
/
Humans
Language:
En
Journal:
Expert Opin Ther Pat
Journal subject:
TERAPEUTICA
Year:
2024
Document type:
Article
Affiliation country:
China