Research progress on GPX4 targeted compounds.
Eur J Med Chem
; 274: 116548, 2024 Aug 05.
Article
in En
| MEDLINE
| ID: mdl-38838547
ABSTRACT
Blocking the System Xc-_ GSH_GPX4 pathway to induce ferroptosis in tumor cells is a novel strategy for cancer treatment. GPX4 serves as the core of the System Xc-/GSH/GPX4 pathway and is a predominant target for inducing ferroptosis in tumor cells. This article summarizes compounds identified in current research that directly target the GPX4 protein, including inhibitors, activators, small molecule degraders, chimeric degraders, and the application of combination therapies with other drugs, aiming to promote further research on the target and related diseases.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phospholipid Hydroperoxide Glutathione Peroxidase
Limits:
Animals
/
Humans
Language:
En
Journal:
Eur J Med Chem
/
Eur. j. med. chem
/
European journal of medicinal chemistry
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Francia