The adipokines progranulin and omentin can directly regulate feline ovarian granulosa cell functions.
Res Vet Sci
; 175: 105321, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38843689
ABSTRACT
The aim of the present study was to determine the effects of the adipokines progranulin and omentin on the basic functions of feline ovarian cells. For this purpose, we investigated the effects of the addition of progranulin and omentin (0, 0.1, 1, or 10 ng/ml) on the proliferation (accumulation of PCNA and cyclin B1), apoptosis (accumulation of Bax and caspase 3) and progesterone release of cultured feline ovarian granulosa cells by quantitative immunocytochemistry and enzyme-linked immunosorbent assays (ELISAs). Both progranulin and omentin increased cell proliferation and decreased apoptosis. Both progranulin and omentin promoted progesterone release. The present findings demonstrate that the adipokines progranulin and omentin can directly regulate basic feline ovarian cell functions.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Apoptosis
/
Cell Proliferation
/
Granulosa Cells
Limits:
Animals
Language:
En
Journal:
Res Vet Sci
Year:
2024
Document type:
Article