Mast cell activation syndrome: Current understanding and research needs.
J Allergy Clin Immunol
; 154(2): 255-263, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38851398
ABSTRACT
Mast cell activation syndrome (MCAS) is a term applied to several clinical entities that have gained increased attention from patients and medical providers. Although several descriptive publications about MCAS exist, there are many gaps in knowledge, resulting in confusion about this clinical syndrome. Whether MCAS is a primary syndrome or exists as a constellation of symptoms in the context of known inflammatory, allergic, or clonal disorders associated with systemic mast cell activation is not well understood. More importantly, the underlying mechanisms and pathways that lead to mast cell activation in MCAS patients remain to be elucidated. Here we summarize the known literature, identify gaps in knowledge, and highlight research needs. Covered topics include contextualization of MCAS and MCAS-like endotypes and related diagnostic evaluations; mechanistic research; management of typical and refractory symptoms; and MCAS-specific education for patients and health care providers.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mastocytosis
/
Mast Cells
Limits:
Animals
/
Humans
Language:
En
Journal:
J Allergy Clin Immunol
Year:
2024
Document type:
Article
Country of publication:
Estados Unidos