Urinary D-amino acid profiles in cats with chronic kidney disease.
J Vet Med Sci
; 86(8): 855-859, 2024 Aug 02.
Article
in En
| MEDLINE
| ID: mdl-38853004
ABSTRACT
Chronic kidney disease (CKD) is highly prevalent in domestic cats. This study aimed to compare urinary D-amino acid levels between control and CKD-afflicted cats as a novel noninvasive method for assessing CKD. Cats were divided into control and CKD stage II groups in accordance with the International Renal Interest Society guidelines. The urinary DL-amino acid levels of the cats were analyzed using chiral tandem liquid chromatography-tandem mass spectrometry, and their medical records were investigated. The CKD group had considerably lower urinary D-amino acid concentrations and enantiomeric ratios than the control group. The total urinary D-amino acid contents significantly correlated with blood parameters (creatinine and urea nitrogen). These findings may contribute towards the detection of CKD stage II in domestic cats.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cat Diseases
/
Renal Insufficiency, Chronic
/
Amino Acids
Limits:
Animals
Language:
En
Journal:
J Vet Med Sci
Journal subject:
MEDICINA VETERINARIA
Year:
2024
Document type:
Article
Affiliation country:
Japón