Interplay of hippocampal long-term potentiation and long-term depression in enabling memory representations.
Philos Trans R Soc Lond B Biol Sci
; 379(1906): 20230229, 2024 Jul 29.
Article
in En
| MEDLINE
| ID: mdl-38853558
ABSTRACT
Hippocampal long-term potentiation (LTP) and long-term depression (LTD) are Hebbian forms of synaptic plasticity that are widely believed to comprise the physiological correlates of associative learning. They comprise a persistent, input-specific increase or decrease, respectively, in synaptic efficacy that, in rodents, can be followed for days and weeks in vivo. Persistent (>24 h) LTP and LTD exhibit distinct frequency-dependencies and molecular profiles in the hippocampal subfields. Moreover, causal and genetic studies in behaving rodents indicate that both LTP and LTD fulfil specific and complementary roles in the acquisition and retention of spatial memory. LTP is likely to be responsible for the generation of a record of spatial experience, which may serve as an associative schema that can be re-used to expedite or facilitate subsequent learning. In contrast, LTD may enable modification and dynamic updating of this representation, such that detailed spatial content information is included and the schema is rendered unique and distinguishable from other similar representations. Together, LTP and LTD engage in a dynamic interplay that supports the generation of complex associative memories that are resistant to generalization. This article is part of a discussion meeting issue 'Long-term potentiation 50 years on'.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Long-Term Potentiation
/
Long-Term Synaptic Depression
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Hippocampus
/
Memory
Limits:
Animals
/
Humans
Language:
En
Journal:
Philos Trans R Soc Lond B Biol Sci
Year:
2024
Document type:
Article
Affiliation country:
Alemania
Country of publication:
Reino Unido