Effectiveness of nirsevimab immunoprophylaxis against respiratory syncytial virus-related outcomes in hospital and primary care settings: a retrospective cohort study in infants in Catalonia (Spain).
Arch Dis Child
; 109(9): 736-741, 2024 Aug 16.
Article
in En
| MEDLINE
| ID: mdl-38857952
ABSTRACT
BACKGROUND:
In Catalonia, infants under 6 months old were eligible to receive nirsevimab, a novel monoclonal antibody against respiratory syncytial virus (RSV). We aimed to analyse nirsevimab's effectiveness across primary and hospital care outcomes.METHODS:
Retrospective cohort study from 1 October 2023 to 31 January 2024, including all infants born between April and September 2023. We established two cohorts based on nirsevimab administration (immunised and non-immunised). We followed individuals until the earliest moment of an outcome-RSV infection, primary care attended bronchiolitis and pneumonia, hospital emergency visits due to bronchiolitis, hospital admission or intensive care unit (ICU) admission due to RSV bronchiolitis-death or the end of the study. We used the Kaplan-Meier estimator and fitted Cox regression models using a calendar time scale to estimate HRs and their 95% CIs.RESULTS:
Among 26 525 infants, a dose of nirsevimab led to an adjusted HR for hospital admission due to RSV bronchiolitis of 0.124 (95% CI 0.086 to 0.179) and an adjusted HR for ICU admission of 0.099 (95% CI 0.041 to 0.237). Additionally, the adjusted HRs observed for emergency visits were 0.446 (95% CI 0.385 to 0.516) and 0.393 (95% CI 0.203 to 0.758) for viral pneumonia, 0.519 (95% CI 0.467 to 0.576) for bronchiolitis attended in primary care and 0.311 (95% CI 0.200 to 0.483) for RSV infection.CONCLUSION:
We demonstrated nirsevimab's effectiveness with reductions of 87.6% and 90.1% in hospital and ICU admissions, respectively. These findings offer crucial guidance for public health authorities in implementing RSV immunisation campaigns.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Primary Health Care
/
Respiratory Syncytial Virus Infections
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Antibodies, Monoclonal, Humanized
/
Hospitalization
Limits:
Female
/
Humans
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Infant
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Male
/
Newborn
Country/Region as subject:
Europa
Language:
En
Journal:
Arch Dis Child
/
Arch. dis. child
/
Archives of disease in childhood
Year:
2024
Document type:
Article
Affiliation country:
España
Country of publication:
Reino Unido