Future avenues in Drosophila mushroom body research.
Learn Mem
; 31(5)2024 May.
Article
in En
| MEDLINE
| ID: mdl-38862172
ABSTRACT
How does the brain translate sensory information into complex behaviors? With relatively small neuronal numbers, readable behavioral outputs, and an unparalleled genetic toolkit, the Drosophila mushroom body (MB) offers an excellent model to address this question in the context of associative learning and memory. Recent technological breakthroughs, such as the freshly completed full-brain connectome, multiomics approaches, CRISPR-mediated gene editing, and machine learning techniques, led to major advancements in our understanding of the MB circuit at the molecular, structural, physiological, and functional levels. Despite significant progress in individual MB areas, the field still faces the fundamental challenge of resolving how these different levels combine and interact to ultimately control the behavior of an individual fly. In this review, we discuss various aspects of MB research, with a focus on the current knowledge gaps, and an outlook on the future methodological developments required to reach an overall view of the neurobiological basis of learning and memory.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mushroom Bodies
/
Drosophila
Limits:
Animals
Language:
En
Journal:
Learn Mem
/
Learn. mem
/
Learning and memory
Journal subject:
NEUROLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Alemania
Country of publication:
Estados Unidos