Metagenomic next-generation sequencing reveals co-infection with Legionella pneumophila and Fusobacterium necrophorum in a patient with severe pneumonia: a case report.
BMC Pulm Med
; 24(1): 279, 2024 Jun 12.
Article
in En
| MEDLINE
| ID: mdl-38867173
ABSTRACT
BACKGROUND:
Legionella pneumonia is one of the most severe types of atypical pneumonia, impairing multiple organ systems, posing a threat to life. Diagnosing Legionella pneumonia is challenging due to difficulties in culturing the bacteria and limitations in immunoassay sensitivity and specificity. CASE PRESENTATION This paper reports a rare case of sepsis caused by combined infection with Legionella pneumophila and Fusobacterium necrophorum, leading to respiratory failure, acute kidney injury, acute liver injury, myocardial damage, and electrolyte disorders. In addition, we systematically reviewed literature on patients with combined Legionella infections, analyzing their clinical features, laboratory results and diagnosis.CONCLUSIONS:
For pathogens that require prolonged incubation periods and are less sensitive to conventional culturing methods, metagenomic next-generation sequencing (mNGS) can be a powerful supplement to pathogen screening and plays a significant role in the auxiliary diagnosis of complex infectious diseases.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Legionnaires' Disease
/
Legionella pneumophila
/
High-Throughput Nucleotide Sequencing
/
Coinfection
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Fusobacterium Infections
/
Fusobacterium necrophorum
Limits:
Humans
/
Male
/
Middle aged
Language:
En
Journal:
BMC Pulm Med
Year:
2024
Document type:
Article
Affiliation country:
China