Digitoxose as powerful glycosyls for building multifarious glycoconjugates of natural products and un-natural products.
Synth Syst Biotechnol
; 9(4): 701-712, 2024 Dec.
Article
in En
| MEDLINE
| ID: mdl-38868608
ABSTRACT
Digitoxose, a significant 2,6-dideoxyhexose found in nature, exists in many small-molecule natural products. These digitoxose-containing natural products can be divided into steroids, macrolides, macrolactams, anthracyclines, quinones, enediynes, acyclic polyene, indoles and oligosaccharides, that exhibit antibacterial, anti-viral, antiarrhythmic, and antitumor activities respectively. As most of digitoxose-containing natural products for clinical application or preclinical tests, this review also summarizes the biosynthesis of digitoxose, and application of compound diversification by introducing sugar plasmids. It may provide a practical approach to expanding the diversity of digitoxose-containing products.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Synth Syst Biotechnol
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
China