Monoclonal gammopathy-associated peripheral neuropathies: Uncovering pearls and challenges.
J Peripher Nerv Syst
; 29(2): 161-172, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38873841
ABSTRACT
Monoclonal gammopathy-related peripheral neuropathies encompass a spectrum of clinical presentations in which the monoclonal protein directly damages the tissues, including the peripheral nervous system. Given the prevalence of both peripheral neuropathy and monoclonal gammopathy in the general population, these conditions may overlap in clinical practice, posing a challenge for clinicians in determining causality. Therefore, a comprehensive understanding of primary clinical syndromes and their neurophysiological patterns is of great importance for accurate differential diagnoses and effective treatment strategies. In this article, we examine the main forms of monoclonal gammopathies that affect the peripheral nerve. We explore the clinical and electrophysiological aspects and their correlation with each syndrome's corresponding monoclonal protein type. This knowledge is essential for healthcare professionals to diagnose better and manage patients presenting with monoclonal gammopathy-related peripheral nervous system involvement.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Paraproteinemias
/
Peripheral Nervous System Diseases
Limits:
Humans
Language:
En
Journal:
J Peripher Nerv Syst
Journal subject:
NEUROLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Brasil
Country of publication:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA