Therapeutic potential of Phycocyanin in gastrointestinal cancers and related disorders.
Mol Biol Rep
; 51(1): 741, 2024 Jun 14.
Article
in En
| MEDLINE
| ID: mdl-38874869
ABSTRACT
Gastrointestinal cancer is the most fatal cancer worldwide. The etiology of gastrointestinal cancer has yet to be fully characterized. Alcohol consumption, obesity, tobacco, Helicobacter pylori and gastrointestinal disorders, including gastroesophageal reflux disease, gastric ulcer, colon polyps and non-alcoholic fatty liver disease are among the several risks factors for gastrointestinal cancers. Phycocyanin which is abundant in Spirulina. Phycocyanin, a member of phycobiliprotein family with intense blue color, is an anti-diabetic, neuroprotective, anti-oxidative, anti-inflammatory, and anticancer compound. Evidence exists supporting that phycocyanin has antitumor effects, exerting its pharmacological effects by targeting a variety of cellular and molecular processes, i.e., apoptosis, cell-cycle arrest, migration and Wnt/ß-catenin signaling. Phycocyanin has also been applied in treatment of several gastrointestinal disorders such as, gastric ulcer, ulcerative colitis and fatty liver that is known as a risk factor for progression to cancer. Herein, we summarize various cellular and molecular pathways that are affected by phycocyanin, its efficacy upon combined drug treatment, and the potential for nanotechnology in its gastrointestinal cancer therapy.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phycocyanin
/
Gastrointestinal Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Mol Biol Rep
/
Mol. Biol. reports
/
Molecular biology reports
Year:
2024
Document type:
Article
Affiliation country:
Irán
Country of publication:
Países Bajos