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In vivo emergence of cefiderocol and ceftazidime/avibactam cross-resistance in KPC-producing Klebsiella pneumoniae following ceftazidime/avibactam -based therapies.
Amadesi, Stefano; Amedeo, Alberto; Rinaldi, Matteo; Palombo, Marta; Giannella, Maddalena; Gaibani, Paolo.
Affiliation
  • Amadesi S; Division of Microbiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Amedeo A; Clinical Infectious Diseases Unit IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Rinaldi M; Clinical Infectious Diseases Unit IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
  • Palombo M; Division of Microbiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Giannella M; Clinical Infectious Diseases Unit IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
  • Gaibani P; Department of Diagnostic and Public Health, Microbiology Section, Verona University, Verona, Italy. Electronic address: paolo.gaibani@univr.it.
Diagn Microbiol Infect Dis ; 110(1): 116372, 2024 Sep.
Article in En | MEDLINE | ID: mdl-38875893
ABSTRACT
We described the emergence of ceftazidime/avibactam and cefiderocol cross-resistance in patients with KPC-producing Klebsiella pneumoniae infections. All strains with ceftazidime/avibactam and cefiderocol cross-resistance showed point mutations on KPC Ω-loop. Taken together, our results indicate that prolonged exposure to ceftazidime/avibactam can confer cross-resistance to ceftazidime/avibactam and cefiderocol.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Beta-Lactamases / Klebsiella Infections / Microbial Sensitivity Tests / Ceftazidime / Cephalosporins / Drug Resistance, Multiple, Bacterial / Drug Combinations / Azabicyclo Compounds / Cefiderocol / Klebsiella pneumoniae Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Diagn Microbiol Infect Dis / Diagn. microbiol. infect. dis / Diagnostic microbiology and infectious disease Year: 2024 Document type: Article Affiliation country: Italia Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Beta-Lactamases / Klebsiella Infections / Microbial Sensitivity Tests / Ceftazidime / Cephalosporins / Drug Resistance, Multiple, Bacterial / Drug Combinations / Azabicyclo Compounds / Cefiderocol / Klebsiella pneumoniae Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Diagn Microbiol Infect Dis / Diagn. microbiol. infect. dis / Diagnostic microbiology and infectious disease Year: 2024 Document type: Article Affiliation country: Italia Country of publication: Estados Unidos