The role and mechanism of SUMO modification in liver disease.
Biomed Pharmacother
; 177: 116898, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38878635
ABSTRACT
Liver disease affects millions of people in the world, and China has the highest prevalence of liver disease in the world. Small ubiquitin-related modifier (SUMO) modification is a highly conserved post-translational modification of proteins. They are widely expressed in a variety of tissues, including the heart, liver, kidney and lung. SUMOylation of protein plays a key role in the occurrence and development of liver disease. Therefore, this study reviewed the effects of SUMO protein on non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), viral hepatitis, hepatic fibrosis (HF), hepatocellular carcinoma (HCC), and other liver diseases to provide novel strategies for targeted treatment of liver disease.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Small Ubiquitin-Related Modifier Proteins
/
Sumoylation
/
Liver Diseases
Limits:
Animals
/
Humans
Language:
En
Journal:
Biomed Pharmacother
Year:
2024
Document type:
Article
Affiliation country:
China