α7 nicotinic receptor activation mitigates herpes simplex virus type 1 infection in microglia cells.
Antiviral Res
; 228: 105934, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38880195
ABSTRACT
Herpes simplex virus type 1 (HSV-1), a neurotropic DNA virus, establishes latency in neural tissues, with reactivation causing severe consequences like encephalitis. Emerging evidence links HSV-1 infection to chronic neuroinflammation and neurodegenerative diseases. Microglia, the central nervous system's (CNS) immune sentinels, express diverse receptors, including α7 nicotinic acetylcholine receptors (α7 nAChRs), critical for immune regulation. Recent studies suggest α7 nAChR activation protects against viral infections. Here, we show that α7 nAChR agonists, choline and PNU-282987, significantly inhibit HSV-1 replication in microglial BV2 cells. Notably, this inhibition is independent of the traditional ionotropic nAChR signaling pathway. mRNA profiling revealed that choline stimulates the expression of antiviral factors, IL-1ß and Nos2, and down-regulates the apoptosis genes and type A Lamins in BV2 cells. These findings suggest a novel mechanism by which microglial α7 nAChRs restrict viral infections by regulating innate immune responses.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Virus Replication
/
Choline
/
Microglia
/
Herpesvirus 1, Human
/
Alpha7 Nicotinic Acetylcholine Receptor
Limits:
Animals
Language:
En
Journal:
Antiviral Res
Year:
2024
Document type:
Article
Affiliation country:
Estados Unidos