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Altered lymphocyte profiles and herpes zoster infections in patients with multiple sclerosis on natalizumab.
Balshi, Alexandra; Manning, Nova; Dempsey, John; Kumbar, Sachin; Baber, Ursela; Sloane, Jacob A.
Affiliation
  • Balshi A; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Manning N; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Dempsey J; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Kumbar S; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Baber U; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Sloane JA; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Mult Scler ; 30(10): 1370-1373, 2024 Sep.
Article in En | MEDLINE | ID: mdl-38880936
ABSTRACT
Cases of herpes zoster (HZ) in patients with MS on natalizumab (NTZ) have been documented. In this study, we assessed lymphocyte subsets in NTZ-treated patients with HZ compared to matched controls without HZ. Twenty unvaccinated patients developed HZ while on NTZ for an incidence rate of 12.3 per 1000 patient-years. These patients had lower CD8+% and higher CD4+CD8+ ratios (p ⩽ 0.01) than non-HZ matched controls. Two patients with relapsing-remitting MS developed HZ twice while on NTZ. These findings underscore the importance of pre-NTZ HZ vaccination due to potential HZ risk.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Multiple Sclerosis, Relapsing-Remitting / Natalizumab / Herpes Zoster / Immunologic Factors Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Mult Scler / Mult. scler / Multiple sclerosis Journal subject: NEUROLOGIA Year: 2024 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Multiple Sclerosis, Relapsing-Remitting / Natalizumab / Herpes Zoster / Immunologic Factors Limits: Adult / Female / Humans / Male / Middle aged Language: En Journal: Mult Scler / Mult. scler / Multiple sclerosis Journal subject: NEUROLOGIA Year: 2024 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido