Distinct metabolomic and lipidomic profiles in serum samples of patients with primary sclerosing cholangitis.
Front Med (Lausanne)
; 11: 1334865, 2024.
Article
in En
| MEDLINE
| ID: mdl-38895187
ABSTRACT
Intoduction Identification of specific metabolome and lipidome profile of patients with primary sclerosing cholangitis (PSC) is crucial for diagnosis, targeted personalized therapy, and more accurate risk stratification. Methods:
Nuclear magnetic resonance (NMR) spectroscopy revealed an altered metabolome and lipidome of 33 patients with PSC [24 patients with inflammatory bowel disease (IBD) and 9 patients without IBD] compared with 40 age-, sex-, and body mass index (BMI)-matched healthy controls (HC) as well as 64 patients with IBD and other extraintestinal manifestations (EIM) but without PSC.Results:
In particular, higher concentrations of pyruvic acid and several lipoprotein subfractions were measured in PSC in comparison to HC. Of clinical relevance, a specific amino acid and lipid profile was determined in PSC compared with IBD and other EIM.Discussion:
These results have the potential to improve diagnosis by differentiating PSC patients from HC and those with IBD and EIM.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Front Med (Lausanne)
/
Front. med. (Lausanne)
/
Frontiers in medicine (Lausanne)
Year:
2024
Document type:
Article
Affiliation country:
Alemania
Country of publication:
Suiza