CARD9 in the pathogenesis of axial spondyloarthritis.
Best Pract Res Clin Rheumatol
; 38(2): 101964, 2024 05.
Article
in En
| MEDLINE
| ID: mdl-38897880
ABSTRACT
Axial spondyloarthritis (axSpA) has been long classified as an autoimmune disease caused by a breakdown in the ability of the immune system to delineate self from foreign, resulting in self-reactive T cells. The strong genetic association of HLA-B27 supports this role for T cells. More recently, genetic and clinical studies indicate a prominent role of the environment in triggering axSpA, including an important role for microbes and the innate immune response. As an example, mutations in genes associated with innate immunity, including the anti-fungal signaling molecule Caspase recruitment domain-containing protein 9 (CARD9), have been linked to axSpA susceptibility. Thus, current thought classifies axSpA as a "mixed pattern condition" caused by both autoimmune and autoinflammatory mechanisms. The goal of this review is to convey.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
CARD Signaling Adaptor Proteins
/
Axial Spondyloarthritis
Limits:
Humans
Language:
En
Journal:
Best Pract Res Clin Rheumatol
Journal subject:
REUMATOLOGIA
Year:
2024
Document type:
Article
Country of publication:
Países Bajos