Molecular regulators of defective placental and cardiovascular development in fetal growth restriction.
Clin Sci (Lond)
; 138(13): 761-775, 2024 Jul 03.
Article
in En
| MEDLINE
| ID: mdl-38904187
ABSTRACT
Placental insufficiency is one of the major causes of fetal growth restriction (FGR), a significant pregnancy disorder in which the fetus fails to achieve its full growth potential in utero. As well as the acute consequences of being born too small, affected offspring are at increased risk of cardiovascular disease, diabetes and other chronic diseases in later life. The placenta and heart develop concurrently, therefore placental maldevelopment and function in FGR may have profound effect on the growth and differentiation of many organ systems, including the heart. Hence, understanding the key molecular players that are synergistically linked in the development of the placenta and heart is critical. This review highlights the key growth factors, angiogenic molecules and transcription factors that are common causes of defective placental and cardiovascular development.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Placenta
/
Fetal Growth Retardation
Limits:
Animals
/
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Clin Sci (Lond)
Year:
2024
Document type:
Article
Affiliation country:
Nueva Zelanda
Country of publication:
Reino Unido