Structurally diverse diterpenoids from the seeds of Caesalpinia minax Hance and their bioactivities.
Phytochemistry
; 225: 114189, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-38905919
ABSTRACT
Eight previously undescribed diterpenoids, caesamins A-H (1-8), were separated and identified from the seeds of Caesalpinia minax Hance. Their structures were characterized by extensive spectroscopic data and X-ray crystallographic analysis. Structurally, caesamin A (1) is the first cassane-type diterpenoid with a C23 carbon skeleton containing an unusual isopropyl. Caesamin F (6) represents the first example of cleistanthane diterpenoid from the genus Caesalpinia. Caesamins B (2) and F (6) exhibited inhibitory activity against LPS-induced nitric oxide production in RAW 264.7 macrophages with IC50 values of 45.67 ± 0.92 and 42.99 ± 0.24 µM, comparable to positive control 43.69 ± 2.62 µM of NG-Monomethyl-L-arginine. Furthermore, the chemotaxonomic significance of the isolates was discussed.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Seeds
/
Caesalpinia
/
Diterpenes
/
Nitric Oxide
Limits:
Animals
Language:
En
Journal:
Phytochemistry
Year:
2024
Document type:
Article