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Get your receptors in a knot with new Wnt signaling agonists.
Wolf, Lucie; Angers, Stephane.
Affiliation
  • Wolf L; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada.
  • Angers S; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada; Leslie Dan Faculty of Pharmacy and Department of Biochemistry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address: stephane.angers@utoronto.ca.
Cell Chem Biol ; 31(6): 1044-1046, 2024 Jun 20.
Article in En | MEDLINE | ID: mdl-38906109
ABSTRACT
Pharmacological modulation of the Wnt/ß-catenin signaling pathway holds promises for both basic research and therapeutic applications. In this issue of Cell Chemical Biology, Kschonsak et al.1 engineered knotted peptides that promote Wnt signaling by targeting ZNRF3 and serve as pharmacological tools for studying Wnt biology and supporting organoid growth.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Wnt Signaling Pathway Limits: Animals / Humans Language: En Journal: Cell Chem Biol Year: 2024 Document type: Article Affiliation country: Canadá

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Wnt Signaling Pathway Limits: Animals / Humans Language: En Journal: Cell Chem Biol Year: 2024 Document type: Article Affiliation country: Canadá