The causal relationship and potential mediators between plasma lipids and atopic dermatitis: a bidirectional two-sample, two-step mendelian randomization.
Lipids Health Dis
; 23(1): 191, 2024 Jun 22.
Article
in En
| MEDLINE
| ID: mdl-38909247
ABSTRACT
BACKGROUND:
Observational studies have indicated that the plasma lipid profiles of patients with atopic dermatitis show significant differences compared to healthy individuals. However, the causal relationship between these differences remains unclear due to the inherent limitations of observational studies. Our objective was to explore the causal effects between 179 plasma lipid species and atopic dermatitis, and to investigate whether circulating inflammatory proteins serve as mediators in this causal pathway.METHODS:
We utilized public genome-wide association studies data to perform a bidirectional two-sample, two-step mendelian randomization study. The inverse variance-weighted method was adopted as the primary analysis technique. MR-Egger and the weighted median were used as supplementary analysis methods. MR-PRESSO, Cochran's Q test, and MR-Egger intercept test were applied for sensitivity analyses to ensure the robustness of our findings.RESULTS:
The Mendelian randomization analysis revealed that levels of Phosphatidylcholine (PC) (181_204) (OR 0.950, 95% CI 0.929-0.972, p = 6.65 × 10- 6), Phosphatidylethanolamine (O-181_204) (OR 0.938, 95% CI 0.906-0.971, p = 2.79 × 10- 4), Triacylglycerol (TAG) (566) (OR 0.937, 95% CI 0.906-0.969, p = 1.48 × 10- 4) and TAG (568) (OR 0.918, 95% CI 0.876-0.961, p = 2.72 × 10- 4) were inversely correlated with the risk of atopic dermatitis. Conversely, PC (181_202) (OR 1.053, 95% CI 1.028-1.079, p = 2.11 × 10- 5) and PC (O-181_203) (OR 1.086, 95% CI 1.039-1.135, p = 2.47 × 10- 4) were positively correlated with the risk of atopic dermatitis. The results of the reverse directional Mendelian randomization analysis indicated that atopic dermatitis exerted no significant causal influence on 179 plasma lipid species. The level of circulating IL-18R1 was identified as a mediator for the increased risk of atopic dermatitis associated with higher levels of PC (181_202), accounting for a mediation proportion of 9.07%.CONCLUSION:
Our research suggests that plasma lipids can affect circulating inflammatory proteins and may serve as one of the pathogenic factors for atopic dermatitis. Targeting plasma lipid levels as a treatment for atopic dermatitis presents a potentially novel approach.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dermatitis, Atopic
/
Genome-Wide Association Study
/
Mendelian Randomization Analysis
Limits:
Humans
Language:
En
Journal:
Lipids Health Dis
/
Lipids health dis. (Online)
/
Lipids in health and disease (Online)
Journal subject:
BIOQUIMICA
/
METABOLISMO
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Reino Unido